SYNTHESIS AND INVITRO ANTIBACTERIAL PROPERTIES OF 2-(3-BROMO-5-ISOXAZOLYLIDENEAMINO-OXY)ACETAMIDO-BETA-LACTAM DERIVATIVES

被引:0
|
作者
SALA, A [1 ]
CHIARINO, D [1 ]
NAPOLETANO, M [1 ]
ALBINI, E [1 ]
CARENZI, A [1 ]
机构
[1] ZAMBON RES LABS,I-20091 BRESSO,ITALY
来源
FARMACO | 1991年 / 46卷 / 7-8期
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中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The synthesis of new 2-(3-bromo-5-isoxazolylideneaminoxy)acetic acids and their condensation derivatives with suitable beta-lactam nuclei is reported. Their antibacterial properties have been tested in vitro. An interesting activity against Gram-positive bacteria including beta-lactamase-producing microorganisms was found among the cephalosporanic acid derivatives.
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页码:887 / 897
页数:11
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