SYNTHESIS AND ANTIESTROGENIC ACTIVITY OF THE COMPOUNDS RELATED TO THE METABOLITES OF (Z)-4-[1-[4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-2-(4-ISOPROPYLPHENYL)-1-BUTENYL]PHENYL MONOPHOSPHATE (TAT-59)

The metabolites of (Z)-4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1-butenyl]phenyl monophosphate, TAT-59, (1), a potent antitumor agent for hormone-dependent tumors, and derivatives of TAT-59 were synthesized to confirm its proposed structure. The structure and the Z-configuration of the metabolites (2a-8a) were confirmed by comparison with synthesized authentic compounds. All of the metabolites and the derivatives of TAT-59 were tested for a binding affinity toward estrogenic receptors in vitro and antiuterotrophic activity in vivo. Most of the metabolites possessed remarkable binding affinity toward estrogenic receptors as well as fairly good antiuterotrophic activity.