ASCORBATE-DEPENDENT ELEVATION OF MESSENGER-RNA LEVELS FOR CYTOCHROME-P450S INDUCED BY POLYCHLORINATED-BIPHENYLS

被引：10
|
作者：
SUZUKI, H [1 ]
TORII, Y [1 ]
HITOMI, K [1 ]
TSUKAGOSHI, N [1 ]
机构：
[1] NAGOYA UNIV,FAC AGR,DEPT APPL BIOL SCI,CHIKUSA KU,NAGOYA 46401,JAPAN
来源：
BIOCHEMICAL PHARMACOLOGY | 1993年 / 46卷 / 01期
关键词：
D O I：
10.1016/0006-2952(93)90365-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Trichlorobiphenyl induced only CYP1A2 mRNA, while pentachlorobiphenyl induced both CYP1A2 and CYP2B1 mRNAs in rat liver. The mRNA levels for these P450s were elevated when ascorbic acid-deficient ODS rats (mutant rats with a hereditary osteogenic disorder) were fed a diet supplemented with ascorbic acid. The amount of CYP2B1 mRNA increased rapidly and reached a maximum level of approximately double within 24 hr of injection of pentachlorobiphenyl. Thereafter, the amount of its mRNA decreased to a steady level. This pattern was roughly paralleled by changes in the amount of CYP1A2 mRNA.
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页码：186 / 189
页数：4
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