CALCIUM-ANTAGONISTS POSTINFARCTION - THE SIGNIFICANCE OF EXPERIMENTAL STUDIES ON POTENTIALLY LETHAL EARLY ISCHEMIC VENTRICULAR ARRHYTHMIAS

被引：4
|
作者：
OPIE, LH
机构：
[1] Ischaemic Heart Disease Research Unit of the Medical Research Council, University of Cape Town Medical School, Observatory, Cape Town
来源：
CARDIOVASCULAR DRUGS AND THERAPY | 1991年 / 5卷 / 04期
关键词：
VERAPAMIL; POST-INFARCT; VENTRICULAR FIBRILLATION; CALCIUM OVERLOAD; AFTERDEPOLARIZATIONS;
D O I：
10.1007/BF03029739
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The DAVIT-II trial [1] has shown that the verapamil type of calcium antagonist can beneficially be used in post-infarct patients. A recent re-analysis suggests that verapamil may also prevent post-infarct sudden death. There are good theoretical reasons to suppose that calcium antagonists should help prevent ventricular fibrillation. If calcium antagonist agents could be found which have negligible negative inotropic effects, such drugs might be ideal for further testing in the post-infarct phase.
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页码：671 / 675
页数：5
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