THE SIMIAN IMMUNODEFICIENCY VIRUS (SIV) REV GENE REGULATES ENV EXPRESSION

被引：0

作者：

CHENG, SM ^{[1
]}

BLUME, M ^{[1
]}

LEE, SG ^{[1
]}

HUNG, PP ^{[1
]}

HIRSCH, VM ^{[1
]}

JOHNSON, PR ^{[1
]}

机构：

[1] GEORGETOWN UNIV,DIV MOLEC VIROL & IMMUNOL,RETROVIRAL PATHOGENESIS SECT,WASHINGTON,DC 20057

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1990年 / 19卷 / 3-4期

关键词：

RNA ANALYSIS; IMMUNOBLOT; SYNCYTIUM FORMATION;

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The rev gene product is a trans-acting nuclear regulatory protein that is essential for AIDS virus replication. To define the effect of the SIV rev gene on its gp160 expression, two SV40 constructs have been made: pBC17 is a rev+env+ construct, and pBD21 is a rev-env+ construct. After transfecting the constructs into COS-1 cells, RNA, protein, syncytium formation, and monoclonal antibody blocking assays were performed. The results indicated that the SIV rev gene positively influenced the level of full-length env mRNA and was required for expression of SIV gp160.

引用

页码：167 / 176

页数：10

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