Study of Body Mass Index and Premenopausal or Postmenopausal Breast Cancer

Introduction: Obesity has increased its role in prevalence of many diseases since the early 1980s, as acknowledged in many studies and strongly suggests that obesity represented by body mass index (BMI) increases the relative risk of premenopausal or postmenopausal breast cancer. Materials and Methods: A retrograde study of total 200 case patients who were newly diagnosed with breast cancer and 200 controls of women ages 35-64 years were taken for the study. The point of this study was Rama Medical College, Hapur, Uttar Pradesh. All subjects were interviewed using a structured questionnaire prepared on demographics, reproductive history, medical history, including weight and height, family history of breast cancer and other life-style factors. BMI was calculated at the age of 18 and recent at the time of diagnosis of breast cancer. Results: Author observed in premenopausal breast cancer women having BMI at 18 years age <20 (reference value) were 50% and in control group 46%. Author calculated the ORBMI (>= 25kg/m2) (versus) (<20 kg/m2) = 0.67. Apart of BMI, maximum cases of weight change since 18 years weight was 5.1-15.0 kg group in premenopausal women 39% and in the control group 38%. In postmenopausal breast cancer women, the odds ratio (OR) found the borderline results. Apart of BMI, maximum cases of weight change since 18 years weight was 5.1-15.0 kg group in postmenopausal women 35% and in control group 31% and OR showed ORweight change 5.1-15 kg versus <5 kg = 1.19. Overall ORBMI >= 25 kg/m2 (versus <20 kg/m2) = 0.67. Conclusion: This study found an inverse association between increasing BMI at age 18 years and risk of breast cancer in women ages 35-64 years especially in premenopausal women. In postmenopausal women, BMI at the age of 18 and recent BMI did not have any significant effect on breast cancer incidence, but weight change from 18 years age to recent had the direct association with breast cancer.