EFFECT OF AGING ON MONOAMINE TURNOVER IN THE PREFRONTAL CORTEX OF RATS

被引：12
|
作者：
VENERO, JL [1 ]
MACHADO, A [1 ]
CANO, J [1 ]
机构：
[1] UNIV SEVILLA, FAC FARM, DEPT BIOQUIM BROMATOL & TOXICOL, E-41012 SEVILLE, SPAIN
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 1993年 / 72卷 / 02期
关键词：
PREFRONTAL CORTEX; TURNOVER; BIOGENIC AMINES; AGING; RAT;
D O I：
10.1016/0047-6374(93)90093-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Turnover of dopamine (DA), serotonin (5-hydroxytryptamine) (5-HT), noradrenaline (NA) and their metabolites has been measured in control and aged rats. In addition, tyrosine hydroxylase (TH) activity has been studied. After pargyline treatment, the turnover rates of DA, NA, 3,4-dihydroxyphenylacetic acid (DOPAC), 3-methoxytyramine (3-MT), 5-HT and 5-hydroxy-3-indolacetic acid (5-HIAA) and TH activity increased in aged rats with respect to controls. At the same time the DA and 3-MT turnover increase are consistent with the hypothesis that enhanced release of DA may participate in some degenerative processes in ageing. After probenecid treatment, the turnover of homovanillic acid (HVA) was lower in aged rats than in controls. However, DOPAC turnover was higher in the aged rats. The DOPAC increase seems to indicate a reinforcement of this pathway in aged rats.
引用
收藏
页码：105 / 118
页数：14
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