RESOLUTION OF CHIRAL [2.2]PARACYCLOPHANES BY ENANTIOSELECTIVE GAS-CHROMATOGRAPHY

被引：26
|
作者：
KONIG, WA [1 ]
GEHRCKE, B [1 ]
HOCHMUTH, DH [1 ]
MLYNEK, C [1 ]
HOPF, H [1 ]
机构：
[1] TECH UNIV CAROLO WILHELMINA BRAUNSCHWEIG,INST ORGAN CHEM,D-38106 BRAUNSCHWEIG,GERMANY
来源：
TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 03期
关键词：
D O I：
10.1016/S0957-4166(00)86203-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
[2.2]Paracyclophanes possessing a substituent on the aromatic ring are dissymmetric compounds due to the restricted rotation of the benzene rings. For interconversion of enantiomers temperatures above 200-degrees-C are necessary. We have succeeded in resolving the enantiomers of some mono-substituted [2.2]paracyclophanes by enantioselective gas chromatography using 2,3-di-O-methylated beta-cyclodextrins with bulky O-(1,1,2-trimethylpropyl)-dimethylsilyl or O-tbutyledimethylsilyl substituents in the 6-position of the glucose units as chiral stationary phases.
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页码：347 / 350
页数：4
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