STATUS EPILEPTICUS RESULTS IN REVERSIBLE NEURONAL INJURY IN INFANT RAT HIPPOCAMPUS - NOVEL USE OF A MARKER

被引：45
|
作者：
CHANG, D
BARAM, TZ
机构：
[1] CHILDRENS HOSP LOS ANGELES,DIV NEUROL 82,4650 SUNSET BLVD,LOS ANGELES,CA 90027
[2] UNIV SO CALIF,DEPT NEUROL,LOS ANGELES,CA 90027
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1994年 / 77卷 / 01期
关键词：
EXCITOTOXICITY; ACID-FUCHSIN; CELL DEATH; SEIZURE; NEONATE; KAINIC ACID; HIPPOCAMPUS;
D O I：
10.1016/0165-3806(94)90220-8
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Despite ready induction of severe limbic status epilepticus by systemic kainic acid (KA) in infant rats, excitotoxic neuronal injury has not been observed. The mechanisms of this resistance of the immature hippocampus to excitotoxicity are unknown. Acid fuchsin stain has been used as a marker of irreversibly injured neurons in the adult brain. We speculated that the dye might map reversibly injured neurons in the infant. Subsequent to KA-induced status epilepticus in 11-day-old rats, acid fuchsin stain was evident in the hippocampal CA3, CA1, dentate gyrus and hilus by 24 h, peaked at 48 h and disappeared by 6 days, without evidence for neuronal loss. Acid fuchsin may be a useful tool for delineating the distribution of reversibly injured immature neurons in experimental seizure paradigms.
引用
收藏
页码：133 / 136
页数：4
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