ON A PRACTICAL SYNTHESIS OF BETA-HYDROXY FATTY-ACID DERIVATIVES

被引：32
|
作者：
OIKAWA, M [1 ]
KUSUMOTO, S [1 ]
机构：
[1] OSAKA UNIV,FAC SCI,DEPT CHEM,TOYONAKA,OSAKA 560,JAPAN
来源：
TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 04期
关键词：
D O I：
10.1016/0957-4166(95)00106-Y
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An efficient synthesis of three homochiral beta-hydroxy fatty acid derivatives, which have been utilized in our total synthesis of lipid A, is reported. The synthesis features Sharpless asymmetric dihydroxylation of an unsaturated ester, regioselective conversion of a diol into acyloxy chlorides, and a reductive removal of the chloro group.
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页码：961 / 966
页数：6
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