INTERFERON MEDIATED PHOSPHATIDYLINOSITOL UPTAKE AND PROCESSING IN NUCLEI ISOLATED FROM BURKITT-LYMPHOMA CELLS

The kinetic analysis of exogenous [H-3]phosphatidylinositol (PI) uptake and processing by nuclei isolated from Daudi lymphoma cells upon interferon alpha treatment has been performed. Results have disclosed that, with respect to controls, interferon induces an evident stimulation of label incorporation into nuclei. The incorporated [H-3] PI has been found for phosphorylation and hydrolytic cleavage, indicating that the intranuclear transduction system activated by interferon at plasma membrane level, might involve the PI cycle as a possible route of intracellular signalling.