ALPHA-1-ADRENOCEPTOR BLOCKING PROPERTIES OF SPIROXATRINE IN RAT AORTA

被引：6
|
作者：
TERRON, JA [1 ]
RANSANZ, V [1 ]
IBARRA, M [1 ]
HONG, E [1 ]
VILLALON, CM [1 ]
机构：
[1] NATL POLYTECH INST,CTR INVEST & ESTUDIOS AVANZADOS,DEPT FARMACOL & TOXICOL,SECC TERAPEUT,MEXICO CITY 14,DF,MEXICO
来源：
LIFE SCIENCES | 1992年 / 51卷 / 01期
关键词：
D O I：
10.1016/0024-3205(92)90222-B
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This preliminary study has analyzed the potential ability of the 5-HT1A ligand spiroxatrine to interact with vascular alpha-1-adrenoceptors. Norepinephrine and the selective alpha-1-adrenoceptor agonist, methoxamine, elicited concentration-dependent contractions of rat aortic rings. In contrast, (+/-)-spiroxatrine (from 10(-8) to 3.1 X 10(-7) M) was devoid of any effect on vascular tone per se, but shifted the concentration-response curves of norepinephrine and methoxamine to the right in a concentration-dependent manner with pA2 values of 8.48 +/- 0.22 and 8.93 +/- 0.33, respectively. Endothelium removal did not significantly affect the above pA2 values of (+/-)-spiroxatrine. These data, taken in concert, support the contention that (+/-)-spiroxatrine displays alpha-1-adrenoceptor blocking properties in rat aortic rings.
引用
收藏
页码：PL1 / PL6
页数：6
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