THE CORRELATION BETWEEN COLLAGEN AND LIPID METABOLISMS IN RESIDENTS OF THE ARCTIC ZONE OF THE RUSSIAN FEDERATION

The purpose of the study is to examine the relationship between collagen metabolism and lipid profile and the risk of cardiovascular pathology in middle-aged men living in the Arctic. Material and methods. The study based on written consent was included apparently healthy middle-aged overweighted men, living and working in the European North (n=28). Anthropometric survey was conducted by measuring body height and weight, waist and hip circumference (WC, HC). Assessment of cardiovascular risk (CVR) was carried out on a scale of SCORE. The comparison group consisted of men, residents of Western Siberia (n=6). Blood and urine sampling was carried out in the morning. In the urine, assessed were the contents of total hydroxyproline (tGOP) and its forms: free (fGOP), peptid-bound (peGOP), protein-bound (prGOP). The serum contents of cholesterol and triglycerides, HDL, LDL, apolipoprotein Al and apolipoprotein B (Apo A1, Apo B), matrix metalloproteinases - MMP-1, MMP-2, MMP-3, MMP-9, tissue inhibitors of matrix metalloproteinases - TIMP-1 and TIMP-2, TIMP-4 were measured. The results were process using Statistica package applications. Results of the study. The northerners had 2 times increase in the content of tGOP mainly due to peGOP and prGOP. The enhanced fibrosis involves local activation of the regulation system, which is manifested as an increase in the content of MMP-1 and MMP-9 and TIMP-1 and TIMP4. Contents of LDL, HDL, Apo A1 and Apo B were in line with the reference values. Atherogenic coefficient in northerners was higher than 3, but less than that in the comparison group, but the cardiovascular risk was higher. Correlations between the contents of the GOP and cardiovascular risk factors, MMP and TIMP were established. Conclusion. Increased cardiovascular risk scale SCORE, a relationship between the content of hydroxyproline and cardiovascular risk factors among northerners are evidences of the involvement of altered collagen metabolism in the pathogenesis of atherosclerosis.