N2S2 TETRADENTATE LIGANDS FOR SOFT CATIONIC SPECIES - PREPARATION OF NEW LIGANDS OF POTENTIAL INTEREST IN NUCLEAR-MEDICINE

被引：0
|
作者：
CHARBONNELJOBIC, G
GUEMAS, JP
ADELAERE, B
PARRAIN, JL
QUINTARD, JP
机构：
[1] FAC SCI & TECH NANTES,SYNTH ORGAN LAB,CNRS,URA 475,F-44072 NANTES 03,FRANCE
[2] CTR UNIV NOUVELLE CALEDONIE,NOUMEA,NEW CALEDONIA
来源：
BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE | 1995年 / 132卷 / 5-6期
关键词：
3H-1,2-DITHIOLE-3-THIONE; 1,3-DIAMINOPROPAN-2-OL; BIS-(ENAMINOTHIOESTER); N2S2 TETRADENTATE LIGAND; N-HYDROXYSUCCINIMIDYL ESTER;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of N2S2 tetradentate ligands of the bis-(enaminothioester) type was carried out starting from 3-(methylthio)-3H-1,2-dithiolylium iodides and diamines. The title compounds, which are potential ligands for soft cationic species, can be obtained from 1,3 diaminopropan-2-ol and subsequently modified into the dissymmetrical succinic acid ester of the ligand and N-hydroxysuccinimide. The appendage of such a linking group on the chelating structure should allow further grafting to monoclonal antibodies in view of potential applications in nuclear medicine.
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收藏
页码：624 / 636
页数：13
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