The TIM barrel - the most frequently occurring folding motif in proteins

被引：128

作者：

Branden, Carl-Ivar ^{[1
]}

机构：

[1] Biomed Ctr, Dept Mol Biol, POB 590, S-75124 Uppsala, Sweden

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1991年 / 1卷 / 06期

关键词：

D O I：

10.1016/0959-440X(91)90094-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TIM-barrel fold has now been found in 19 enzymes with different catalytic functions and different lengths of polypeptide chains. The domain organization of these chains are compared and discussed. For several of these chains, X-ray structures have recently been refined and active-site residues have been identified by studies of inhibitor complexes. Evolutionary implications of these results, including the first examples of evolutionarily related enzymes that catalyze different chemical reactions, are discussed.

引用

页码：978 / 983

页数：6

共 50 条

[1]

[Anonymous], 1999, INTRO PROTEIN STRUCT

[2] STRUCTURE OF CHICKEN MUSCLE TRIOSE PHOSPHATE ISOMERASE DETERMINED CRYSTALLOGRAPHICALLY AT 2.5A RESOLUTION USING AMINO-ACID SEQUENCE DATA [J].

BANNER, DW ;

BLOOMER, AC ;

PETSKO, GA ;

PHILLIPS, DC ;

POGSON, CI ;

WILSON, IA ;

CORRAN, PH ;

FURTH, AJ ;

MILMAN, JD ;

OFFORD, RE ;

PRIDDLE, JD ;

WALEY, SG .

NATURE, 1975, 255 (5510) :609-614

[3] THE MOLECULAR-STRUCTURE AND STABILITY OF THE EYE LENS - X-RAY-ANALYSIS OF GAMMA-CRYSTALLIN-II [J].

BLUNDELL, T ;

LINDLEY, P ;

MILLER, L ;

MOSS, D ;

SLINGSBY, C ;

TICKLE, I ;

TURNELL, B ;

WISTOW, G .

NATURE, 1981, 289 (5800) :771-777

[4] CALCIUM-BINDING IN ALPHA-AMYLASES - AN X-RAY-DIFFRACTION STUDY AT 2.1-A RESOLUTION OF 2 ENZYMES FROM ASPERGILLUS [J].

BOEL, E ;

BRADY, L ;

BRZOZOWSKI, AM ;

DEREWENDA, Z ;

DODSON, GG ;

JENSEN, VJ ;

PETERSEN, SB ;

SWIFT, H ;

THIM, L ;

WOLDIKE, HF .

BIOCHEMISTRY, 1990, 29 (26) :6244-6249

[5] RELATION BETWEEN STRUCTURE AND FUNCTION OF ALPHA-BETA-PROTEINS [J].

BRANDEN, CI .

QUARTERLY REVIEWS OF BIOPHYSICS, 1980, 13 (03) :317-338

[6]

BRANDEN CI, 1986, CURRENT COMMUNICATIO, P45

[7] 3 DIMENSIONAL STRUCTURE OF PORCINE PANCREATIC ALPHA-AMYLASE AT 2.9 A RESOLUTION - ROLE OF CALCIUM IN STRUCTURE AND ACTIVITY [J].

BUISSON, G ;

DUEE, E ;

HASER, R ;

PAYAN, F .

EMBO JOURNAL, 1987, 6 (13) :3909-3916

[8] PROTEIN-STRUCTURE - THE 14TH BARREL ROLLS OUT [J].

CHOTHIA, C .

NATURE, 1988, 333 (6174) :598-599

[9] STRUCTURE OF THE TRIOSEPHOSPHATE ISOMERASE PHOSPHOGLYCOLOHYDROXAMATE COMPLEX - AN ANALOG OF THE INTERMEDIATE ON THE REACTION PATHWAY [J].

DAVENPORT, RC ;

BASH, PA ;

SEATON, BA ;

KARPLUS, M ;

PETSKO, GA ;

RINGE, D .

BIOCHEMISTRY, 1991, 30 (24) :5821-5826

[10] THE EVOLUTION OF ALPHA-BETA-BARREL ENZYMES [J].

FARBER, GK ;

PETSKO, GA .

TRENDS IN BIOCHEMICAL SCIENCES, 1990, 15 (06) :228-&

← 1 2 3 4 5 →