PENTOSTATIN INDUCES DURABLE REMISSIONS IN HAIRY-CELL LEUKEMIA

被引：100
|
作者：
CASSILETH, PA
CHEUVART, B
SPIERS, ASD
HARRINGTON, DP
CUMMINGS, FJ
NEIMAN, RS
BENNETT, JM
OCONNELL, MJ
机构：
[1] HARVARD UNIV,SCH PUBL HLTH,DANA FARBER CANC INST,BOSTON,MA 02115
[2] UNION UNIV,ALBANY,NY 12208
[3] BROWN UNIV,PROVIDENCE,RI 02912
[4] ROGER WILLIAMS GEN HOSP,PROVIDENCE,RI 02908
[5] INDIANA UNIV,MED CTR,INDIANAPOLIS,IN 46204
[6] UNIV ROCHESTER,CTR CANC,ROCHESTER,NY 14627
[7] MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905
来源：
JOURNAL OF CLINICAL ONCOLOGY | 1991年 / 9卷 / 02期
关键词：
D O I：
10.1200/JCO.1991.9.2.243
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fifty patients with hairy cell leukemia were treated with pentostatin (2'-deoxycoformycin; dCF) for a median of 3 months; 32 (64%) patients achieved complete remission (CR), and 10 (20%) patients achieved partial remission (PR), for an overall response rate of 84%. After reaching maximal response, no maintenance therapy was administered. The median duration of follow-up is now 39 months, and only four of 32 patients in CR and two of 10 patients in PR have relapsed. dCF therapy produces durable long-term, disease-free survival in patients with hairy cell leukemia.
引用
收藏
页码：243 / 246
页数：4
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