Mutations in ribosomal proteins: Apoptosis, cell competition, and cancer

被引：9
|
作者：
Baker, Nicholas E. [1 ,2 ,3 ]
Kale, Abhijit
机构：
[1] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10467 USA
[3] Albert Einstein Coll Med, Dept Ophthalmol & Visual Sci, Bronx, NY 10467 USA
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 01期
关键词：
apoptosis; cancer predisposition; Drosophila melanogaster; genetic mosaic; ribosomal protein; somatic mutation;
D O I：
10.1080/23723556.2015.1029065
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mutations affecting multiple ribosomal proteins are implicated in cancer. Using genetic mosaics in the fruit fly Drosophila, we describe 3 apoptotic mechanisms that affect Rp/Rp homozygous mutant cells, Rp/C heterozygous cells, or Rp/C heterozygous cells in competition with nearby wild type cells, and discuss how apoptosis might be related to cancer predisposition.
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收藏
页数：2
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