INFLUENCE OF ENDOTHELIN-1 ON VENTRICULAR-FIBRILLATION THRESHOLD IN ACUTE MYOCARDIAL ISCHEMIC RATS

被引：0
|
作者：
ZHAO, X
FU, WJ
YUAN, WJ
HOU, GX
CHEN, JG
XIA, JH
ZHU, HN
机构：
来源：
ACTA PHARMACOLOGICA SINICA | 1994年 / 15卷 / 04期
关键词：
ENDOTHELINS; MYOCARDIAL ISCHEMIA; ARRHYTHMIA; VENTRICULAR FIBRILLATION; DILTIAZEM;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The influence of endothelin-1 on ventricular fibrillation threshold was studied in acute myocardial ischemic rats. Endothelin-1 (1.5 - 3.0 mu g.kg(-1) iv) given 5 min before ischemia reduced the ventricular fibrillation threshold in a dose- and time-dependent manner. Its effect lasted at least 60 min. marked increase of spontaneous ventricular tachycardia and myocardial infarct size was seen and the arterial blood pressure was at a higher level (18.5 - 20.1/14.4 - 15.8 kPa) after 3.0 mu g.kg(-1). Diltiazem prevented par- tially from reduction of ventricular fibrillation threshold, eliminated completely the vasopressor response and limited the extension of myocardial necrosis induced by endothelin-1.
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页码：363 / 366
页数：4
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