COMBINED CHEMOTHERAPY AND GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) MOBILIZE LARGE NUMBERS OF PERIPHERAL-BLOOD PROGENITOR CELLS IN PRETREATED PATIENTS

被引:9
|
作者
LICKLITER, JD [1 ]
BEGLEY, CG [1 ]
BOYD, AW [1 ]
SZER, J [1 ]
GRIGG, AP [1 ]
机构
[1] ROYAL MELBOURNE HOSP,DEPT CLIN HAEMATOL & MED ONCOL,BONE MARROW TRANSPLANT SERV,PARKVILLE,VIC 3050,AUSTRALIA
基金
英国医学研究理事会;
关键词
PROGENITOR CELL MOBILIZATION; G-CSF; CLONOGENIC ASSAY; CD34; PROGENITOR CELL TRANSPLANTATION;
D O I
10.3109/10428199409051683
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this study was to examine the effect of G-CSF given after salvage chemotherapy on the mobilisation of peripheral blood progenitor cells (PBPC) in pretreated patients. Seven patients with relapsed or refractory non-Hodgkin's lymphoma (NHL) were treated with methotrexate, cyclophosphamide, cytarabine, etoposide and dexamethasone. G-CSF was given at a dose of 3.8-7.2 mu g/kg (1-2 ampoules) daily by subcutaneous injection from the onset of neutropenia (<1.0 x 10(9)/L). A median of 3 leukaphereses was performed when the white cell count was recovering. The median number of granulocyte-macrophage colony-forming cells (GM-CFC) collected was 99 x 10(4)/kg per leucapheresis (range 19-800) or 260 x 10(4)/ kg in total per patient (110-1800). Six patients underwent myeloablative chemotherapy with PBPC rescue. No autologous bone marrow or growth factors post-PBPC infusion were administered. The median duration of severe neutropenia (<0.5 x 10(9)/L) was 8.5 days (range 5-10) and to recovery of neutrophils post-PBPC infusion was 11.5 days (10-15). Severe thrombocytopenia (<20 x 10(9)/L) was present for 4 days (range 1-5) and the median number of days post-infusion to platelet-transfusion independence was 9 (6-12). In conclusion, G-CSF combined with chemotherapy mobilised large numbers of PBPC for subsequent autotransplantation in pretreated patients with NHL. A single leukapheresis procedure may be sufficient following this protocol.
引用
收藏
页码:91 / 97
页数:7
相关论文
共 50 条
  • [1] CHARACTERIZATION OF PERIPHERAL-BLOOD CD34+ PROGENITOR CELLS MOBILIZED WITH CHEMOTHERAPY AND GRANULOCYTE-COLONY-STIMULATING FACTOR
    TEOFILI, L
    IOVINO, MS
    SICA, S
    PIERELLI, L
    MENICHELLA, G
    DESTEFANO, V
    RUMI, C
    LEONE, G
    EXPERIMENTAL HEMATOLOGY, 1994, 22 (10) : 990 - 995
  • [2] PERIPHERAL-BLOOD PROGENITOR-CELL (PBPC) MOBILIZATION WITH CYCLOPHOSPHAMIDE (CY), VP16, AND GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF)
    GHALIE, R
    RICHMAN, C
    MCLEOD, B
    MANSON, S
    KAIZER, H
    EXPERIMENTAL HEMATOLOGY, 1993, 21 (08) : 1129 - 1129
  • [3] GRANULOCYTE-COLONY-STIMULATING FACTOR INDUCES SELECTIVE ELEVATIONS OF PROGENITOR CELLS IN THE PERIPHERAL-BLOOD OF MICE
    ROBERTS, AW
    METCALF, D
    EXPERIMENTAL HEMATOLOGY, 1994, 22 (12) : 1156 - 1163
  • [4] GUIDELINES FOR THE USE OF GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF)
    HARVEY, V
    EVANS, B
    THOMPSON, P
    NEW ZEALAND MEDICAL JOURNAL, 1995, 108 (1006) : 349 - 349
  • [5] OPTIMIZING THE HARVEST OF GRANULOCYTE-COLONY-STIMULATING MOBILIZED PERIPHERAL-BLOOD PROGENITOR CELLS
    BENJAMIN, RJ
    AXELROD, J
    UHL, L
    MALACHOWSKI, ME
    WHEELER, C
    TRANSFUSION, 1994, 34 (10) : S5 - S5
  • [6] COLLECTION OF PERIPHERAL-BLOOD STEM-CELLS FROM PATIENTS WITH VERY HIGH WHITE COUNTS INDUCED BY GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF)
    LASKY, L
    JOHNSON, N
    PEDERSON, B
    EMRICK, E
    RANK, L
    OGLE, K
    FLYNN, PJ
    FLYNN, T
    RANK, B
    TRANSFUSION, 1993, 33 (09) : S45 - S45
  • [7] ADMINISTRATION OF GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) IN SEPTICEMIA IN LEUKEMIC PATIENTS
    MIKRAKI, V
    XAIDARA, A
    NYKTARI, G
    ARMEFTI, A
    CHAROCOPOS, E
    TZORTZATOUSTATHOPOULOU, F
    JOURNAL OF CHEMOTHERAPY, 1993, 5 : 677 - 678
  • [8] VASCULAR COMPLICATIONS IN PATIENTS TREATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF)
    LINDEMANN, A
    RUMBERGER, B
    EUROPEAN JOURNAL OF CANCER, 1993, 29A (16) : 2338 - 2339
  • [9] MOBILIZATION OF HUMAN LONG-TERM CULTURE INITIATING CELLS (LTCIC) INTO PERIPHERAL-BLOOD (PB) BY GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF)
    DOOLEY, D
    SPURGIN, P
    HANSEN, K
    HANSEN, L
    LANIER, K
    MAZIARZ, R
    BLOOD, 1993, 82 (10) : A292 - A292
  • [10] NONCYCLING STATE OF PERIPHERAL-BLOOD PROGENITOR CELLS MOBILIZED BY GRANULOCYTE-COLONY-STIMULATING FACTOR AND OTHER CYTOKINES
    ROBERTS, AW
    METCALF, D
    BLOOD, 1995, 86 (04) : 1600 - 1605