COMBINED K+ AND CL- REPLETION CORRECTS AUGMENTED H+ SECRETION BY DISTAL TUBULES IN CHRONIC ALKALOSIS

被引:9
|
作者
WESSON, DE
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1994年 / 266卷 / 04期
关键词
BICARBONATE; ACIDIFICATION; REABSORPTION; MICROPUNCTURE;
D O I
10.1152/ajprenal.1994.266.4.F592
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
NaCl administration enhances HCO3 secretion in the distal tubule of animals with chronic metabolic alkalosis but does not correct the augmented H+ secretion characteristic of this disorder. The present studies used in vivo microperfusion micropuncture to investigate whether combined repletion of K+ and Cl- corrected the augmented H+ secretion in the distal tubule of rats with chronic furosemide-induced metabolic alkalosis. Correction of alkalosis was induced in one group of animals with NaCl and in another group with a similar amount of Cl- as NaCl + KCl for 24 h; each group was compared with animals with maintained alkalosis. Total 24-h urine HCO3 excretion by each Cl--repleted group comprised greater than or equal to 70% of the calculated HCO3 loss necessary to induce the respective decrease in plasma total CO2. Alkalotic animals given NaCl + KCl had significantly lower H+ secretion in the distal tubule compared with animals with maintained alkalosis (15.5 +/- 1.2 vs. 34.6 +/- 1.8 pmol.mm(-1).min(-1), P < 0.01) but those given only NaCl did not (28.3 +/- 1.5 pmol.mm(-1).min(-1), P = 0.14). H+ secretion was not different among control animals given similar amounts of Na+, K+, and Cl-. These studies demonstrate that Cl- repletion corrects chronic furosemide-induced metabolic alkalosis predominantly by a renal mechanism and that combined administration of K+ and Cl- but not of Cl- alone, corrects the augmented H+ secretion in the distal tubule in this model of chronic alkalosis.
引用
收藏
页码:F592 / F603
页数:12
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