RELATIONSHIP OF ORNITHINE DECARBOXYLASE ACTIVITY AND HUMAN COLON TUMORIGENESIS

被引：0
|
作者：
TAKAMI, H
KOUDAIRA, H
KODAIRA, S
机构：
来源：
JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 1994年 / 24卷 / 03期
关键词：
ORNITHINE DECARBOXYLASE; COLON TUMOR;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ornithine decarboxylase (ODC) activity was determined in tumorous lesions of the human colon, and the possibility of ODC acting as a marker of colon tumorigenesis investigated. In adenoma, ODC activity, in pmoles/h/mg protein, was 164+/-82 in tumorous tissue, which was higher than the 19.6+/-10.5 in macroscopically normal mucosa (control tissue) around the tumorous tissue, while 8.7+/-4.1 in normal colon mucosa. In carcinoma-in-adenoma and carcinoma, ODC activities in the control tissue were 15.3+/-11.9 and 27.5+/-15.0, respectively. The levels were respectively higher than in normal tissue. These results suggest ODC to be a potential indicator of colon tumorigenesis.
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收藏
页码：141 / 143
页数：3
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