CHANNEL FORMATION IN PLANAR LIPID BILAYERS BY A NEUROTOXIC FRAGMENT OF THE BETA-AMYLOID PEPTIDE

被引：108
|
作者：
MIRZABEKOV, T
LIN, MC
YUAN, WL
MARSHALL, PJ
CARMAN, M
TOMASELLI, K
LIEBERBURG, I
KAGAN, BL
机构：
[1] UNIV CALIF LOS ANGELES,INST NEUROPSYCHIAT,DEPT PSYCHIAT & BEHAV SCI,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024
[3] ATHENA NEUROSCI INC,S SAN FRANCISCO,CA 94080
[4] W LOS ANGELES VET AFFAIRS MED CTR,LOS ANGELES,CA 90073
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 202卷 / 02期
关键词：
D O I：
10.1006/bbrc.1994.2047
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) pathology is characterized by plaques, tangles, and neuronal cell loss. The main constituent of plaques is beta-amyloid peptide (A beta), a 39-42 residue peptide which has been linked to disruption of calcium homeostasis and neurotoxicity in vitro. We demonstrate that a neurotoxic fragment of A beta, A beta (25-35) spontaneously inserted into planar lipid membranes to form weakly selective, voltage dependent, ion-permeable channels. We suggest that channel formation may be involved in the pathogenesis of AD and that A beta (25-35) may be the active channel forming segment. (C) 1994 Academic Press, Inc
引用
收藏
页码：1142 / 1148
页数：7
相关论文
共 50 条
  • [1] CHANNELS IN LIPID BILAYERS INDUCED BY A FRAGMENT OF THE BETA-AMYLOID PEPTIDE
    MARSHALL, P
    MIRZABEKOV, T
    YUAN, WL
    CARMAN, M
    LIEBERBURG, I
    KAGAN, B
    BIOPHYSICAL JOURNAL, 1993, 64 (02) : A94 - A94
  • [2] Aggregation of amyloid beta peptide and formation of ion channel activity in planar lipid bilayers
    Prangkio, Panchika
    Capone, Ricardo
    Yang, Jerry
    Mayer, Michael
    BIOPHYSICAL JOURNAL, 2007, : 612A - 612A
  • [3] Channel formation by a neurotoxic beta amyloid peptide, A beta 25-35
    Lin, MC
    Mirzabekov, T
    Kagan, B
    NEURODEGENERATIVE DISEASES: MOLECULAR AND CELLULAR MECHANISMS AND THERAPEUTIC ADVANCES, 1996, : 331 - 336
  • [4] AGGREGATION STATE AND NEUROTOXIC PROPERTIES OF ALZHEIMER BETA-AMYLOID PEPTIDE
    HOWLETT, DR
    JENNINGS, KH
    LEE, DC
    CLARK, MSG
    BROWN, F
    WETZEL, R
    WOOD, SJ
    CAMILLERI, P
    ROBERTS, GW
    NEURODEGENERATION, 1995, 4 (01): : 23 - 32
  • [5] Aggregation of Beta-Amyloid Peptides Proximal to Zwitterionic Lipid Bilayers
    Yang, Chien-I
    Tsai, Brook N. F.
    Huang, Shing-Jong
    Wang, Ting-Yu
    Tai, Hwan-Ching
    Chan, Jerry C. C.
    CHEMISTRY-AN ASIAN JOURNAL, 2015, 10 (09) : 1967 - 1971
  • [6] Cholesterol modulates amyloid beta peptide 1-42 channel formation in planar lipid membranes
    Meleleo, D.
    Notarachille, G.
    Gallucci, E.
    Micelli, S.
    NEW TRENDS IN ALZHEIMER AND PARKINSON RELATED DISORDERS: ADPD 2009, 2009, : 167 - 171
  • [7] The interaction of the neurodegenerative fragment of the beta-amyloid peptide with phospholipid membranes
    VanVeen, M
    OShea, P
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1995, 23 (04) : S547 - S547
  • [8] TRANSGLUTAMINASE FACILITATES THE FORMATION OF POLYMERS OF THE BETA-AMYLOID PEPTIDE
    DUDEK, SM
    JOHNSON, GVW
    BRAIN RESEARCH, 1994, 651 (1-2) : 129 - 133
  • [9] Free radicals in the neurotoxic actions of beta-amyloid
    Richardson, JS
    Zhou, Y
    Kumar, U
    NEUROBIOLOGY OF ALZHEIMER'S DISEASE, 1996, 777 : 362 - 367
  • [10] BETA-AMYLOID IS NEUROTOXIC IN HIPPOCAMPAL SLICE CULTURES
    HARRIGAN, MR
    KUNKEL, DD
    NGUYEN, LB
    MALOUF, AT
    NEUROBIOLOGY OF AGING, 1995, 16 (05) : 779 - 789
12345