Role of T regulatory Cells with Valvular Heart Disease.

The present study was conducted to investigate the associated of t-reg. cells with valvular heart disease, which occurs as a result of different heart disease including (endocarditis, pericarditis and myocarditis) in addition to other diseases, eighty blood samples of patients suffering from various heart disease were collected from hospitals of middle Euphrates region at the period from November 2014-to-May 2015. Flow cytometry technique was used to measure level of T regulatory cells in the blood of patients and determine the proportion of T cells and their markers (CD4, CD25 and Foxp3). Patients show significant difference in CD4, CD25 and Foxp3 rate than controls, while no significant difference in T helper cells level in the same study group. The highest percentage of cells T reg recorded in Coronary Artery Disease(CAD), Congenital Heart Disease (CHD) and Pericarditis by particularly aged over 50 years (47.5%), followed by age groups ranging between (41-50 years)with rate 22.5%.