CALNEXIN - A MEMBRANE-BOUND CHAPERONE OF THE ENDOPLASMIC-RETICULUM

被引：476
作者：
BERGERON, JJM
BRENNER, MB
THOMAS, DY
WILLIAMS, DB
机构：
[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT RHEUMATOL & IMMUNOL,BOSTON,MA 02115
[2] NATL RES COUNCIL CANADA,BIOTECHNOL RES INST,GENET GRP,MONTREAL H4P 2R2,PQ,CANADA
[3] UNIV TORONTO,DEPT BIOCHEM,TORONTO M5S 1A8,ON,CANADA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 03期
关键词：
D O I：
10.1016/0968-0004(94)90205-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calnexin is a new type of molecular chaperone that interacts with many nascent membrane and soluble proteins of the secretory pathway. Calnexin is unrelated to molecular chaperones of the Hsp60, Hsp70 and Hsp90 families, and is further distinguished from them in that it is an integral membrane protein. One of its demonstrated functions is the retention of incorrectly or incompletely folded proteins, suggesting that calnexin is a component of the quality control system of the endoplasmic reticulum.
引用
收藏
页码：124 / 128
页数：5
相关论文
共 27 条
[1]  
AHLUWALIA N, 1992, J BIOL CHEM, V267, P10914
[2]  
CALA SE, 1993, J BIOL CHEM, V268, P2969
[3]   EFFICIENT DISSOCIATION OF THE P88 CHAPERONE FROM MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULES REQUIRES BOTH BETA-2-MICROGLOBULIN AND PEPTIDE [J].
DEGEN, E ;
COHENDOYLE, MF ;
WILLIAMS, DB .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (06) :1653-1661
[4]   PARTICIPATION OF A NOVEL 88-KD PROTEIN IN THE BIOGENESIS OF MURINE CLASS-I HISTOCOMPATIBILITY MOLECULES [J].
DEGEN, E ;
WILLIAMS, DB .
JOURNAL OF CELL BIOLOGY, 1991, 112 (06) :1099-1115
[5]   CNE1, A SACCHAROMYCES-CEREVISIAE HOMOLOG OF THE GENES ENCODING MAMMALIAN CALNEXIN AND CALRETICULIN [J].
DEVIRGILIO, C ;
BURCKERT, N ;
NEUHAUS, JM ;
BOLLER, T ;
WIEMKEN, A .
YEAST, 1993, 9 (02) :185-188
[6]   GLYCOSIDASE INHIBITORS - INHIBITORS OF N-LINKED OLIGOSACCHARIDE PROCESSING [J].
ELBEIN, AD .
FASEB JOURNAL, 1991, 5 (15) :3055-3063
[7]   THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ANTIGEN-BINDING PROTEIN-P88 IS THE PRODUCT OF THE CALNEXIN GENE [J].
GALVIN, K ;
KRISHNA, S ;
PONCHEL, F ;
FROHLICH, M ;
CUMMINGS, DE ;
CARLSON, R ;
WANDS, JR ;
ISSELBACHER, KJ ;
PILLAI, S ;
OZTURK, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) :8452-8456
[8]  
HAMMOND C, IN PRESS P NATL ACAD
[9]  
HAWN TR, 1993, J BIOL CHEM, V268, P7692
[10]  
Helenius Ari, 1992, Trends in Cell Biology, V2, P227, DOI 10.1016/0962-8924(92)90309-B
123