THE EFFECT OF ENDOTHELIN, NEUROPEPTIDE-Y, CALCITONIN-GENE-RELATED PEPTIDE AND SUBSTANCE-P ON NEUTROPHIL FUNCTIONS

被引：41
|
作者：
HAFSTROM, I
RINGERTZ, B
LUNDEBERG, T
PALMBLAD, J
机构：
[1] KAROLINSKA INST,STOCKHOLM SODER HOSP,DEPT MED,S-11883 STOCKHOLM,SWEDEN
[2] KAROLINSKA INST,DEPT PHYSIOL,S-10401 STOCKHOLM 60,SWEDEN
来源：
ACTA PHYSIOLOGICA SCANDINAVICA | 1993年 / 148卷 / 03期
关键词：
AGGREGATION; ENDOTHELIN; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM; CHEMILUMINESCENCE; CHEMOTAXIS; NEUROPEPTIDE-Y; NEUTROPHILS; PMN; SUBSTANCE-P;
D O I：
10.1111/j.1748-1716.1993.tb09565.x
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Neuropeptides are putative mediators of inflammation. At physiological concentrations substance P has been shown to prime polymorphonuclear neutrophil granulocyte (PMN) chemiluminescence (CL). In the present study we show also that both endothelin and neuropeptide Y (NPY), but not calcitonin gene-related peptide (CGRP) are able to prime PMN oxidative metabolism. At similar nanomolar concentrations SP and endothelin (but not NPY) also primed formyl-methionyl-leucyl-phenylalanine (fMLP)-induced rises of cytosolic calcium. On the other hand, NPY caused a direct and dose-related increase of cytosolic calcium concentrations. None of the mentioned neuropeptides primed PMN aggregation or directly induced CL, aggregation or chemotaxis over a wide range of concentrations (1 fM-1 muM).
引用
收藏
页码：341 / 346
页数：6
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