COMPUTER-GRAPHICS MODELING AND MOLECULAR-DYNAMICS SIMULATION OF THE CORE OF THE SELF SPLICING INTERVENING SEQUENCE OF THE T4 NRDB MESSENGER-RNA IN THE PRESENCE OF THE GUANOSINE COFACTOR

被引：0

作者：

NILSSON, L ^{[1
]}

AHGRENSTALHANDSKE, A ^{[1
]}

SJOGREN, AS ^{[1
]}

HAHNE, S ^{[1
]}

SJOBERG, BM ^{[1
]}

机构：

[1] UNIV STOCKHOLM,DEPT MOLEC BIOL,S-10691 STOCKHOLM,SWEDEN

来源：

NUCLEOSIDES & NUCLEOTIDES | 1992年 / 11卷 / 01期

关键词：

D O I：

10.1080/07328319208021158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The active site of the self splicing intron in the T4 nrdB RNA has been modelled on a graphics workstation on the basis of the suggested 3D arrangement of the Tetrahymena IVS. This structure was then subjected to energy minimization and molecular dynamics simulation to relax tensions. The cofactor guanosine was docked to a proposed binding site where it was found to fit well.

引用

页码：159 / 166

页数：8

共 2 条

[1] COMPUTER-GRAPHICS MODELING AND MOLECULAR-DYNAMICS SIMULATION OF THE CORE OF THE SELF SPLICING INTERVENING SEQUENCE OF THE T4 NRDB MESSENGER-RNA IN THE PRESENCE OF THE GUANOSINE COFACTOR
NILSSON, L
AHGRENSTALHANDSKE, A
SJOGREN, AS
HAHNE, S
SJOBERG, BM
NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3): : 207 - 213
[2] 3-DIMENSIONAL MODEL AND MOLECULAR-DYNAMICS SIMULATION OF THE ACTIVE-SITE OF THE SELF-SPLICING INTERVENING SEQUENCE OF THE BACTERIOPHAGE-T4 NRDB MESSENGER-RNA
NILSSON, L
AHGRENSTALHANDSKE, A
SJOGREN, AS
HAHNE, S
SJOBERG, BM
BIOCHEMISTRY, 1990, 29 (45) : 10317 - 10322

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