THE EFFECTS OF COMPLEXATION WITH HYDROGENATED PHOSPHOLIPID ON THE TRANSPORT OF SALICYLIC-ACID, DICLOFENAC AND INDOMETHACIN ACROSS SNAKE STRATUM-CORNEUM

被引：12
|
作者：
BHATTACHAR, SN
RYTTING, JH
ITOH, T
NISHIHATA, T
机构：
[1] UNIV KANSAS,DEPT PHARMACEUT CHEM,3006 MALOTT HALL,LAWRENCE,KS 66045
[2] UPJOHN TUKUBA RES CTR,TSUKUBA,IBARAKI 305,JAPAN
[3] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 79卷 / 2-3期
关键词：
COMPLEXATION; HYDROGENATED PHOSPHOLIPID; NSAID; TRANSDERMAL DRUG DELIVERY;
D O I：
10.1016/0378-5173(92)90119-M
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hydrogenated phospholipid (HPL) has been found to form complexes with three non-steroidal anti-inflammatory drugs: salicylic acid, diclofenac and indomethacin. The solubility of the salicylic acid complex in squalane was less than that of the plain drug, but the solubilities of the diclofenac and indomethacin complex increased upon complexation. The permeability coefficients of salicylic acid and diclofenac across shed snake skin are not affected significantly by the presence of hydrogenated phospholipid. However, the permeability coefficient for the indomethacin-HPL complex is about double that for either plain indomethacin or an indomethacin-HPL physical mixture.
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页码：263 / 271
页数：9
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