A CLUSTER OF RELATED ZINC FINGER PROTEIN GENES IS DELETED IN THE MOUSE EMBRYONIC LETHAL MUTATION TW18

被引：54

作者：

CROSSLEY, PH ^{[1
]}

LITTLE, PFR ^{[1
]}

机构：

[1] IMPERIAL COLL SCI TECHNOL & MED,DEPT BIOCHEM,LONDON SW7 2AZ,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 18期

关键词：

T-COMPLEX; PARTIAL T-HAPLOTYPE; GENE CLUSTER; DELETION; GASTRULATION;

D O I：

10.1073/pnas.88.18.7923

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report that a number of related zinc finger protein genes are closely linked on mouse chromosome 17. At least four of these genes are transcribed in the 8.5-day postcoitum embryo and are deleted in the t complex early acting embryonic lethal mutation t(w18). We have evidence that additional finger protein genes are located in this region. These findings demonstrate that related ringer protein genes can be clustered in the murine genome and identify genes that may be considered as candidates for the t(w18) mutation.

引用

页码：7923 / 7927

页数：5

共 28 条

[1] XFIN - AN EMBRYONIC GENE ENCODING A MULTIFINGERED PROTEIN IN XENOPUS [J].

ALTABA, AR ;

PERRYOKEEFE, H ;

MELTON, DA .

EMBO JOURNAL, 1987, 6 (10) :3065-3070

[2] THE HUMAN GENOME CONTAINS HUNDREDS OF GENES-CODING FOR FINGER PROTEINS OF THE KRUPPEL TYPE [J].

BELLEFROID, EJ ;

LECOCQ, PJ ;

BENHIDA, A ;

PONCELET, DA ;

BELAYEW, A ;

MARTIAL, JA .

DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1989, 8 (06) :377-387

[3] THE DROSOPHILA DEVELOPMENTAL GENE SNAIL ENCODES A PROTEIN WITH NUCLEIC-ACID BINDING FINGERS [J].

BOULAY, JL ;

DENNEFELD, C ;

ALBERGA, A .

NATURE, 1987, 330 (6146) :395-398

[4] THE PRIMARY STRUCTURE OF TRANSCRIPTION FACTOR TFIIIA HAS 12 CONSECUTIVE REPEATS [J].

BROWN, RS ;

SANDER, C ;

ARGOS, P .

FEBS LETTERS, 1985, 186 (02) :271-274

[5] DELETION AND DUPLICATION OF DNA-SEQUENCES IS ASSOCIATED WITH THE EMBRYONIC LETHAL PHENOTYPE OF THE T9 COMPLEMENTATION GROUP OF THE MOUSE T-COMPLEX [J].

BUCAN, M ;

HERRMANN, BG ;

FRISCHAUF, AM ;

BAUTCH, VL ;

BODE, V ;

SILVER, LM ;

MARTIN, GR ;

LEHRACH, H .

GENES & DEVELOPMENT, 1987, 1 (04) :376-385

[6] GENOMIC SEQUENCING [J].

CHURCH, GM ;

GILBERT, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07) :1991-1995

[7]

FAHNER K, 1987, EMBO J, V6, P1265

[8] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[9] A MODEL FOR THE TERTIARY STRUCTURE OF THE 28-RESIDUE DNA-BINDING MOTIF (ZINC FINGER) COMMON TO MANY EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS [J].

GIBSON, TJ ;

POSTMA, JPM ;

BROWN, RS ;

ARGOS, P .

PROTEIN ENGINEERING, 1988, 2 (03) :209-218

[10] EVOLUTION OF MOUSE CHROMOSOME-17 AND THE ORIGIN OF INVERSIONS ASSOCIATED WITH T-HAPLOTYPES [J].

HAMMER, MF ;

SCHIMENTI, J ;

SILVER, LM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3261-3265

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