ADHESION FORCES BETWEEN INDIVIDUAL LIGAND-RECEPTOR PAIRS

被引：1628

作者：

FLORIN, EL ^{[1
]}

MOY, VT ^{[1
]}

GAUB, HE ^{[1
]}

机构：

[1] TECH UNIV MUNICH,DEPT PHYS,D-85748 GARCHING,GERMANY

来源：

SCIENCE | 1994年 / 264卷 / 5157期

关键词：

D O I：

10.1126/science.8153628

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The adhesion force between the tip of an atomic force microscope cantilever derivatized with avidin and agarose beads functionalized with biotin, desthiobiotin, or iminobiotin was measured. Under conditions that allowed only a limited number of molecular pairs to interact, the force required to separate tip and bead was found to be quantized in integer multiples of 160 +/- 20 piconewtons for biotin and 85 +/- 15 piconewtons for iminobiotin. The measured force quanta are interpreted as the unbinding forces of individual molecular pairs.

引用

页码：415 / 417

页数：3

共 24 条

[1]

[Anonymous], 1992, INTERMOLECULAR SURFA

[2] OPTICAL TRAPPING AND MANIPULATION OF SINGLE CELLS USING INFRARED-LASER BEAMS [J].