A Study on Association of Single Nucleotide Polymorphisms on CACNA1A Gene with Migraine in South Indian Population

Mechanism based migraine therapy gained steam in early 1990s and has led to an extensive research for improved understanding of genetics of classical and common migraine, as each has its own hereditary characteristics. This has steered the researchers to associate single nucleotide polymorphisms (SNPs) to migraine. rs16023 of CACNA1A gene is one among the SNPs that are localized for classical migraine. The study was conducted with cohort of 28 volunteers of South Indian origin comprising of 20 volunteers reporting migraine and 8 without migraine. Also in this cohort 16 were common migraineurs and 4 were classical migraineurs. The results of this study indicated that all the 3 female classical migraineurs out of the 4 classical migraineurs exhibited A to T polymorphism which points to the fact that, females are more prone to migraine and also females of South Indian origin show association of rs16023 SNP to classical migraine.