ANTIMICROBIAL ACTIVITY OF JUGLONE

被引:68
|
作者
CLARK, AM
JURGENS, TM
HUFFORD, CD
机构
[1] Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, Mississippi
关键词
antifungal; antimicrobial; athlete's foot; Juglans nigra; Juglone;
D O I
10.1002/ptr.2650040104
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The juice of freshly macerated unripe hulls of the black walnut (Juglans nigra) has been used for many years in folk medicine as a treatment for localized, topical fungal infections such as ringworm. It has been proposed that the biological activity of the walnut hulls is due to the presence of the simple naphthoquinone, juglone (5‐hydroxy‐1,4‐naphthoquinone), which has been isolated from the unripe hulls by sublimation. Since the fresh juice of unripe walnut hulls is utilized for the treatment of ringworm, and since it has been speculated that the activity is due to the presence of juglone, it was of interest to determine the efficacy of juglone as compared to standard commercially available antifungal agents. The comparative efficacy was determined by evaluation of the minimum inhibitory concentration (MIC) values of juglone and the standard antifungal agents clotrimazole, triacetin, tolnaftate, griseofulvin, zinc undecylenate, selenium sulfide as well as two investigational antifungal antibiotics, liriodenine and liriodenine methiodide, for two dermatophytes, Trichophyton mentagrophytes and Microsporum gypseum. MIC values for juglone showed it to have moderate antifungal activity and to be as effective as certain commercially available antifungal agents such as zinc undecylenate and selenium sulfide. Copyright © 1990 John Wiley & Sons, Ltd.
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页码:11 / 14
页数:4
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