Pancreatic Cancer: Promises and Failures of Target Therapies

被引:7
|
作者
Aroldi, Francesca [1 ]
Bertocchi, Paola [1 ]
Rosso, Edoardo [2 ]
Prochilo, Tiziana [1 ]
Zaniboni, Alberto [1 ]
机构
[1] Fdn Poliambulanza, UO Oncol Med, Brescia, Italy
[2] Fdn Poliambulanza, Dept Surg, Brescia, Italy
关键词
Angiogenesis; hedgehog-; JAK-STAT; -notch; immunotherapy; pancreatic cancer; stroma; target therapies;
D O I
10.2174/1574887110666150930122720
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Currently, few efficient therapies are available to battle pancreatic cancer. Mechanisms underlying this cancer are not well known and researchers are trying to identify new therapeutic targets. Here, we present a review of new treatments and their results in recent years.
引用
收藏
页码:33 / 38
页数:6
相关论文
共 50 条
  • [1] Targeted therapies in pancreatic cancer: Promises and failures
    Bagherabad, Matineh Barati
    Afzaljavan, Fahimeh
    ShahidSales, Soodabeh
    Hassanian, Seyed Mahdi
    Avan, Amir
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (03) : 2726 - 2741
  • [2] Targeting stroma in pancreatic cancer: Promises and failures of targeted therapies
    Bahrami, Afsane
    Khazaei, Majid
    Bagherieh, Fariba
    Ghayour-Mobarhan, Majid
    Maftouh, Mina
    Hassanian, Seyed Mahdi
    Avan, Amir
    JOURNAL OF CELLULAR PHYSIOLOGY, 2017, 232 (11) : 2931 - 2937
  • [3] New target therapies in advanced pancreatic cancer
    Cascinu, S.
    Verdecchia, L.
    Valeri, N.
    Berardi, R.
    Scartozzi, M.
    ANNALS OF ONCOLOGY, 2006, 17 : V148 - V152
  • [4] Molecular Features and Targeted Therapies in Extrahepatic Cholangiocarcinoma: Promises and Failures
    Rizzo, Alessandro
    Tavolari, Simona
    Ricci, Angela Dalia
    Frega, Giorgio
    Palloni, Andrea
    Relli, Valeria
    Salati, Massimiliano
    Fenocchio, Elisabetta
    Massa, Annamaria
    Aglietta, Massimo
    Brandi, Giovanni
    CANCERS, 2020, 12 (11) : 1 - 15
  • [5] Target Therapies in Pancreatic Carcinoma
    Silvestris, Nicola
    Gnoni, Antonio
    Brunetti, Anna Elisabetta
    Vincenti, Leonardo
    Santini, Daniele
    Tonini, Giuseppe
    Merchionne, Francesca
    Maiello, Evaristo
    Lorusso, Vito
    Nardulli, Patrizia
    Azzariti, Amalia
    Reni, Michele
    CURRENT MEDICINAL CHEMISTRY, 2014, 21 (08) : 948 - 965
  • [6] EXPECTATIONS AND FAILURES OF CANCER THERAPIES
    MOORE, GE
    CANCER GENETICS AND CYTOGENETICS, 1989, 39 (01) : 4 - 5
  • [7] Sialyl-Tn glycan epitope as a target for pancreatic cancer therapies
    Abrantes, Rafaela
    Lopes, Joanne
    Lopes, Daniel
    Gomes, Joana
    Melo, Sonia A.
    Reis, Celso A.
    FRONTIERS IN ONCOLOGY, 2024, 14
  • [8] Pancreatic Exocrine Insufficiency and the Gut Microbiome in Pancreatic Cancer: A Target for Future Diagnostic Tests and Therapies?
    Halle-Smith, James M.
    Hall, Lewis A.
    Powell-Brett, Sarah F.
    Merali, Nabeel
    Frampton, Adam E.
    Beggs, Andrew D.
    Moss, Paul
    Roberts, Keith J.
    CANCERS, 2023, 15 (21)
  • [9] Pancreatic Cancer Therapies
    Tuveson, D.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S16 - S16
  • [10] Immunosuppression: Promises and failures
    Oger, Joel
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 259 (1-2) : 74 - 78