DOWN SYNDROME CLINICAL SYMPTOMS ARE MANIFESTED IN TRANSFECTED CELLS AND TRANSGENIC MICE OVEREXPRESSING THE HUMAN CU/ZN-SUPEROXIDE DISMUTASE GENE

被引：0
|
作者：
GRONER, Y
ELROYSTEIN, O
AVRAHAM, KB
YAROM, R
SCHICKLER, M
KNOBLER, H
ROTMAN, G
机构：
[1] KAPLAN HOSP, DEPT MED, IL-76100 REHOVOT, ISRAEL
[2] HEBREW UNIV JERUSALEM, HADASSAH MED SCH, DEPT PATHOL, IL-91010 JERUSALEM, ISRAEL
来源：
JOURNAL DE PHYSIOLOGIE | 1990年 / 84卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
引用
收藏
页码：53 / 77
页数：25
相关论文
共 50 条
  • [1] Altered expression of hypothetical proteins in hippocampus of transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1
    Shin J.-H.
    Yang J.-W.
    Le Pecheur M.
    London J.
    Hoeger H.
    Lubec G.
    Proteome Science, 2 (1)
  • [2] THYMIC ABNORMALITIES AND ENHANCED APOPTOSIS OF THYMOCYTES AND BONE-MARROW CELLS IN TRANSGENIC MICE OVEREXPRESSING CU/ZN-SUPEROXIDE DISMUTASE - IMPLICATIONS FOR DOWN-SYNDROME
    PELEDKAMAR, M
    LOTEM, J
    OKON, E
    SACHS, L
    GRONER, Y
    EMBO JOURNAL, 1995, 14 (20): : 4985 - 4993
  • [3] Early thymic T cell development in young transgenic mice overexpressing human Cu/Zn superoxide dismutase, a model of Down syndrome
    Laurent, Julien
    Paly, Evelyne
    Marche, Patrice N.
    London, Jacqueline
    FREE RADICAL BIOLOGY AND MEDICINE, 2006, 40 (11) : 1971 - 1980
  • [4] TRANSGENIC MICE WITH INCREASED CU/ZN-SUPEROXIDE DISMUTASE ACTIVITY - ANIMAL-MODEL OF DOSAGE EFFECTS IN DOWN-SYNDROME
    EPSTEIN, CJ
    AVRAHAM, KB
    LOVETT, M
    SMITH, S
    ELROYSTEIN, O
    ROTMAN, G
    BRY, C
    GRONER, Y
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (22) : 8044 - 8048
  • [5] EXPRESSION OF HUMAN CU-ZN SUPEROXIDE-DISMUTASE GENE IN TRANSGENIC MICE - MODEL FOR GENE DOSAGE EFFECT IN DOWN-SYNDROME
    CEBALLOS, I
    NICOLE, A
    BRIAND, P
    GRIMBER, G
    DELACOURTE, A
    FLAMENT, S
    BLOUIN, JL
    THEVENIN, M
    KAMOUN, P
    SINET, PM
    FREE RADICAL RESEARCH COMMUNICATIONS, 1991, 12-3 : 581 - 589
  • [6] Peroxidative activity of human Cu,Zn-superoxide dismutase
    Kim, SM
    Kang, JH
    MOLECULES AND CELLS, 1997, 7 (01) : 120 - 124
  • [7] Pharmaceutical studies for gene therapy: Expression of human Cu,Zn-superoxide dismutase gene transfected by lipofection in rat skin fibroblasts
    Nishiguchi, K
    Ishida, K
    Nakajima, M
    Maeda, T
    Komada, F
    Iwakawa, S
    Tanigawara, Y
    Okumura, K
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1996, 19 (08) : 1073 - 1077
  • [8] Transgenic mice for the human superoxide dismutase gene: A model for studying aging in Down syndrome
    London, J
    Therond, P
    Paris, D
    Casanova, M
    Nabarra, B
    Toyama, K
    Sinet, PM
    CYTOGENETICS AND CELL GENETICS, 1997, 77 : 29 - 29
  • [9] DIMINISHED SEROTONIN UPTAKE IN PLATELETS OF TRANSGENIC MICE WITH INCREASED CU/ZN-SUPEROXIDE DISMUTASE ACTIVITY
    SCHICKLER, M
    KNOBLER, H
    AVRAHAM, KB
    ELROYSTEIN, O
    GRONER, Y
    EMBO JOURNAL, 1989, 8 (05): : 1385 - 1392
  • [10] IMPAIRED NEUROTRANSMITTER UPTAKE IN PC12 CELLS OVEREXPRESSING HUMAN CU/ZN-SUPEROXIDE DIMUTASE - IMPLICATION FOR GENE DOSAGE EFFECTS IN DOWN SYNDROME
    ELROYSTEIN, O
    GRONER, Y
    CELL, 1988, 52 (02) : 259 - 267
12345