New concepts of glucose-induced insulin secretion in the development of type 2 diabetes: clinical implications

被引:2
|
作者
Dedov, I. I. [1 ]
Smirnova, O. M. [1 ]
Kononenko, I., V [1 ]
机构
[1] Endocrinol Res Ctr, Moscow, Russia
来源
DIABETES MELLITUS | 2015年 / 18卷 / 03期
关键词
pathogenesis; the insulin secretion; signaling pathways; drugs action;
D O I
10.14341/DM2015323-31
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The prevalence of type 2 diabetes is increasing dramatically, and the pathogenesis of the disease has been studied extensively in recent years. Of particular interest, incretins are reported to cause changes in insulin secretion that affect the natural development of the disease. The emergence of new drugs that act via the incretin axis have led many clinicians to consider their place in clinical practice.
引用
收藏
页码:23 / 31
页数:9
相关论文
共 50 条
  • [1] A novel treatment for type 2 diabetes: A glucose-induced insulin secretion by imidazolines
    Mest, HJ
    Raap, A
    Schloos, J
    Treines, I
    Paal, M
    Glese, U
    Koivisto, V
    DIABETOLOGIA, 2000, 43 : A125 - A125
  • [2] Bezafibrate could prevent the development of diabetes by preservation of glucose-induced insulin secretion in type 2 diabetic model rats
    Hasegawa, N
    Ogawa, Y
    Tazawa, Y
    Umeda, Y
    Katayama, Y
    Nakamura, T
    Suda, T
    DIABETES, 2000, 49 : A283 - A283
  • [3] Glucose-induced inhibition of insulin secretion
    Hellman, B.
    Grapengiesser, E.
    ACTA PHYSIOLOGICA, 2014, 210 (03) : 479 - 488
  • [4] Is Endogenous GLP-1 the Only Important Enhancer of Glucose-Induced Insulin Secretion in Type 2 Diabetes?
    Deacon, Carolyn F.
    DIABETES, 2012, 61 (09) : 2219 - 2220
  • [5] Glucose-induced insulin secretion is potentiated by a new imidazoline compound
    Hans-Jürgen Mest
    Achim Raap
    Jürgen Schloos
    Iris Treinies
    Michael Paal
    Ulrich Giese
    Veikko Koivisto
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2001, 364 : 47 - 52
  • [6] Glucose-induced insulin secretion is potentiated by a new imidazoline compound
    Mest, HJ
    Raap, A
    Schloos, J
    Treinies, I
    Paal, M
    Giese, U
    Koivisto, V
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2001, 364 (01) : 47 - 52
  • [7] MECHANISM OF GLUCOSE-INDUCED INSULIN-SECRETION
    HEDESKOV, CJ
    PHYSIOLOGICAL REVIEWS, 1980, 60 (02) : 442 - 509
  • [8] Imperatorin modulates glucose-induced insulin secretion
    Patyra, A.
    Neasta, J.
    Vaille, J.
    Peraldi-Roux, S.
    Kiss, A.
    Oiry, C.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2023, 37 : 105 - 105
  • [9] Near normalisation of blood glucose improves the secretion of amylin during GLP-1 potentiation of glucose-induced insulin secretion in patients with type 2 diabetes
    Asmar, M.
    Hojberg, P.
    Holst, J.
    Madsbad, S.
    DIABETOLOGIA, 2008, 51 : S256 - S256
  • [10] Near normalisation of blood glucose improves the potentiating effect of GLP-1 on glucose-induced insulin secretion in patients with type 2 diabetes
    P. V. Højberg
    M. Zander
    T. Vilsbøll
    F. K. Knop
    T. Krarup
    A. Vølund
    J. J. Holst
    S. Madsbad
    Diabetologia, 2008, 51 : 632 - 640