PRESENCE OF BOTH STIMULATING AND BLOCKING TYPES OF TSH-RECEPTOR ANTIBODIES IN SERA FROM 3 PATIENTS WITH PRIMARY HYPOTHYROIDISM

被引：26
|
作者：
KASAGI, K
TAKEDA, K
GOSHI, K
TAKAMATSU, J
HIDAKA, A
HATABU, H
MISAKI, T
IIDA, Y
KUMA, K
KONISHI, J
机构：
[1] KYOTO UNIV, DEPT NUCL MED, KYOTO 606, JAPAN
[2] KUMA HOSP, KOBE, JAPAN
[3] OSAKA MED COLL, DEPT INTERNAL MED, DIV 1, TAKATSUKI, OSAKA 569, JAPAN
[4] HYOGO PREFECTURAL CHILDRENS HOSP, KOBE, JAPAN
来源：
CLINICAL ENDOCRINOLOGY | 1990年 / 32卷 / 02期
关键词：
D O I：
10.1111/j.1365-2265.1990.tb00861.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A case report of three patients with primary hypothyroidism who had potent TSH‐binding inhibitor immunoglobulins (TBII) and both thyroid stimulating (TSAb) and thyroid stimulation‐blocking antibodies (TSBAb) has been described. Two patients displayed symptoms and signs indistinguishable from those in primary myxoedema (cases 1 and 2), and another patient had a history of Graves'disease (case 3). TBII, TSAb and TSBAb activities were 90.0, 1084.2 and 94.5% in case 1, 91.5, 826.6 and 95.8% in case 2, 76.0, 230.0 and 95.0% in case 3, respectively (normal range, < 11.0%, < 145.0 and < 22.0%, respectively. The results indicate that both stimulating and blocking types of TSH‐receptor antibodies exist in these patients. The possible mechanism whereby hypothyroidism developed has been discussed. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：253 / 260
页数：8
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