REQUIREMENT OF ETS-2 EXPRESSION FOR XENOPUS OOCYTE MATURATION

被引：41
|
作者：
CHEN, ZQ [1 ]
BURDETT, LA [1 ]
SETH, AK [1 ]
LAUTENBERGER, JA [1 ]
PAPAS, TS [1 ]
机构：
[1] NCI,MOLEC ONCOL LAB,FREDERICK,MD 21701
来源：
SCIENCE | 1990年 / 250卷 / 4986期
关键词：
D O I：
10.1126/science.2255913
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A molecular clone of the Xenopus laevis ets-2 gene was isolated from an oocyte complementary DNA library. The amount of messenger RNA (mRNA) in each oocyte or embryo was almost constant during oogenesis and was maintained until the blastula stage of embryonic development, indicating that the observed 3.2-kilobase transcript is a maternal message. The only normal adult tissue in which ets-2 mRNA was detected was the ovary. Injection of antisense oligonucleotides homologous to the ets-2 sequence into oocytes led to degradation of the mRNA and blocked hormone-induced germinal vesicle breakdown. The ets-2 product is thus required for the meiotic maturation of Xenopus oocytes.
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收藏
页码：1416 / 1418
页数：3
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