RATE OF WEAR OF PHARMACEUTICAL TABLETS

被引：0
|
作者：
HWANG, RC
PARROTT, EL
机构：
[1] Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, IA
来源：
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 11期
关键词：
D O I：
10.3109/03639049309074403
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several methods are presented to quantitatively measure the wear of compressed tablets. The natural logarithm of the weight fraction, W/W(O), decreases linearly with increasing wear time. Thus, the wearability of a tablet may be described by a first-order rate constant or its half life. As the wear process continues there may be more than a single rate constant depending on the geometry and structural homogeneity of the tablet.
引用
收藏
页码：1317 / 1329
页数：13
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