REVERSIBLE BINDING OF NITRIC-OXIDE BY A SALIVARY HEME PROTEIN FROM A BLOODSUCKING INSECT

被引：287
|
作者：
RIBEIRO, JMC
HAZZARD, JMH
NUSSENZVEIG, RH
CHAMPAGNE, DE
WALKER, FA
机构：
[1] UNIV ARIZONA,DEPT BIOCHEM,TUCSON,AZ 85721
[2] UNIV ARIZONA,DEPT CHEM,TUCSON,AZ 85721
来源：
SCIENCE | 1993年 / 260卷 / 5107期
关键词：
D O I：
10.1126/science.8386393
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The bloodsucking bug Rhodnius prolixus has a salivary vasodilator, previously characterized as a nitrovasodilator, with salivary smooth muscle-relaxing and antiplatelet activity. Rhodnius salivary glands are bright red owing to the abundance of heme proteins. Electron paramagnetic resonance and optical spectroscopic experiments indicated that the salivary vasodilator is a nitrosylheme protein with an Fe(III) heme that binds nitric oxide (NO) reversibly. Dilution of the protein in neutral pH promoted NO release. This protein thus appears to be the NO carrier that helps R. prolixus to feed on blood.
引用
收藏
页码：539 / 541
页数：3
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