Role of brown and perivascular adipose tissue in vascular complications due to obesity

The contribution of brown and perivascular adipose tissues to the pathophysiology of metabolic and vascular complications associated with obesity are analysed in this review. To combat obesity and prevent its highly prevalent metabolic and vascular complications, a new insight on our knowledge of the role of the thermogenic function of brown adipose tissue and its promising therapeutic potential in humans is needed in addition to conventional treatments. Owing to the impact of brown adipose tissue on energy expenditure related to lipid and glucose metabolism, as well as its potential resistance against inflammation along with perivascular adipose tissue, new perspectives in the treatment of obesity treatment could be focused on the design of new drugs, or different regimens or therapies, that increase the amount and activity of brown adipose tissue. These new treatments not only may contribute to combat obesity, but also prevent complications such as type 2 diabetes and other associated metabolic and vascular changes. (c) 2012 Elsevier Espana, S.L. and SEA. All rights reserved.