STUDY ON THE SUPPRESSIVE EFFECT OF IODINE-ENRICHED EGG ON LT-C4 PRODUCTION IN ARACHIDONIC ACID-INDUCED EAR INFLAMMATION

被引：0
|
作者：
ISONO, E
INOUE, H
AIHARA, M
KUBOTA, T
ANDO, K
ISHIDA, H
机构：
[1] Department of Plastic and Reconstructive Surgery, St. Marianna University School of Medicine, Kawasaki, 216, 2-16-1 Sugao, Miyamae
来源：
LIFE SCIENCES | 1993年 / 53卷 / 13期
关键词：
D O I：
10.1016/0024-3205(93)90265-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The anti- inflammatory mechanism of iodine-enriched egg was investigated in mice by means of arachidonic acid- induced ear inflammation. The lipid fraction of iodine-enriched egg was capable of suppressing the increase in ear weight induced by arachidonic acid in a dose-dependent manner. The lipid fraction was further separated into neutral and polar lipid fractions. Of these two fractions, only the neutral lipid fraction was capable of suppressing LT-C4 production in arachidonic acid inflammation. Neither the neutral nor polar lipid fractions of ordinary egg, however, showed any anti-inflammatory effect. These results suggest that the anti-inflammatory activity of iodine-enriched egg is present in the neutral lipid fraction, and its mechanism is assumed to be inhibition of LT-C4 production.
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页码：PL207 / PL212
页数：6
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