ACETOGENIC ISOQUINOLINE ALKALOIDS .17. 1ST TOTAL SYNTHESIS OF (-)-DIONCOPHYLLINE-A (TRIPHYOPHYLLINE) AND OF SELECTED STEREOISOMERS - COMPLETE (REVISED) STEREOSTRUCTURE

被引:79
|
作者
BRINGMANN, G [1 ]
JANSEN, JR [1 ]
REUSCHER, H [1 ]
RUBENACKER, M [1 ]
PETERS, K [1 ]
VONSCHNERING, HG [1 ]
机构
[1] MAX PLANCK INST FESTKORPERFORSCH,W-7000 STUTTGART 80,GERMANY
关键词
D O I
10.1016/S0040-4039(00)94589-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first total synthesis of dioncophylline A (previously "triphyophylline") and some selected stereoisomers is described, using an intramolecular-type mixed aryl coupling method via ester-type prefixed molecular moieties. Simultaneously, this synthesis establishes the complete (revised) stereostructure of dioncophylline A as 1a, which is thereby the first fully elucidated naphthylisoquinoline alkaloid of Dioncophyllaceae. © 1990.
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页码:643 / 646
页数:4
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