EFFECT OF A DRY BOLDO EXTRACT ON ORO CECAL INTESTINAL TRANSIT-TIME IN HEALTHY-VOLUNTEERS

Background: Boldo (Peumus boldus Molina) is a widely used medicinal plant. However, its physiological effects are not well known. Recent studies in animals showed that certain components of boldo relax smooth muscle and prolong intestinal transit. Aim: to assess the effects of a dry boldo extract on oro cecal transit time in normal humans. Subjects and methods: Twelve volunteers received 2.5 g of a dry boldo extract or a placebo (glucose) during two successive periods of four days. On the fourth day, 20 g of lactulose were administered and breath hydrogen was collected every 15 min. Oro cecal transit time was defined as the time in which breath hydrogen increased by 20 ppm over the fasting level. Results: Oro cecal transit time was larger after dry boldo extract administration, compared to placebo (112.5 +/- 15.4 and 87 +/- 11.8 min respectively, paired t p< 0.05). Conclusions: Dry boldo extract prolongs oro cecal transit time, a possible explanation for its medicinal use.