PALLADIUM CATALYZED INTRAMOLECULAR COUPLING OF ARYL AND BENZYLIC HALIDES AND RELATED TANDEM CYCLIZATIONS - A SIMPLE SYNTHESIS OF HIPPADINE

被引：62
|
作者：
GRIGG, R
TEASDALE, A
SRIDHARAN, V
机构：
[1] School of Chemistry, Leeds University, Leeds
来源：
TETRAHEDRON LETTERS | 1991年 / 32卷 / 31期
关键词：
D O I：
10.1016/S0040-4039(00)79397-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Pd(0)/R3Sn)2 (R = Me or n-Bu) catalyst system effects intramolecular aryl-aryl, benzyl-aryl, benzyl-benzyl coupling of aryl and benzyl halides in good yield. Polycyclisations can be achieved by relaying the coupling via an alkene or alkyne ''linker''. The methodology is exemplified by a short synthesis of hippadine.
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页码：3859 / 3862
页数：4
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