ACUTE LYMPHOBLASTIC-LEUKEMIA FOLLOWING HODGKINS-DISEASE IS ASSOCIATED WITH A GOOD PROGNOSIS

被引：8
|
作者：
NARAYANAN, MN
MORGENSTERN, GR
CHANG, JC
HARRISON, CJ
RANSON, M
SCARFFE, JH
机构：
[1] CHRISTIE HOSP,DEPT MED ONCOL,MANCHESTER,LANCS,ENGLAND
[2] PATERSON INST CANC RES,REG CYTOGENET SERV,MANCHESTER,LANCS,ENGLAND
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 86卷 / 04期
关键词：
ACUTE LYMPHOBLASTIC LEUKEMIA; HODGKINS DISEASE; SECONDARY; PROGNOSIS;
D O I：
10.1111/j.1365-2141.1994.tb04844.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.
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收藏
页码：867 / 869
页数：3
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