DOWN-REGULATION OF THE HUMAN C-FOS AND C-MYC PROTOONCOGENE PROMOTERS BY ADENOASSOCIATED VIRUS REP78

被引：67

作者：

HERMONAT, PL ^{[1
]}

机构：

[1] UNIV ARKANSAS MED SCI HOSP,DEPT MICROBIOL & IMMUNOL,LITTLE ROCK,AR 72205

来源：

CANCER LETTERS | 1994年 / 81卷 / 02期

关键词：

C-FAS; C-MYC; ADENOASSOCIATED VIRUS; REP78; ANTIONCOGENE;

D O I：

10.1016/0304-3835(94)90193-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adeno-associated virus (AAV) is a non-pathogenic human parvovirus which has anti-tumor and anti-proliferation properties in tissue culture and animal studies. Furthermore, AAV infection is negatively associated with human cervical cancer. C-myc has been implicated in cervical cancer, and c-fos is involved in signal transduction initiation of cell growth. To study the potential regulation of these two prominent human proto-oncogenes by AAV, the expression of three marker coding sequences ligated 3' of the proto-oncogene promoters were observed. Demonstrated here, the AAV Rep78 gene product was able to down-regulate the human c-fos and c-myc proto-oncogene promoters in all three assay systems. These interactions may partially explain AAVs anti-proliferation properties.

引用

页码：129 / 136

页数：8

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