SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF SOME NEW THIENO-[2,3-B]QUINOLINES

被引：20
|
作者：
ABDELRAHMAN, AE [1 ]
BAKHITE, EA [1 ]
ABDELMONEAM, MI [1 ]
MOHAMED, TA [1 ]
机构：
[1] UNIV ASSIUT,FAC SCI,DEPT CHEM,ASSIUT,EGYPT
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1992年 / 73卷 / 1-4期
关键词：
THIENOQUINOLINES; PYRIMIDIOTHIENOQUINOLINES AND TRIAZINOTHIENOQUINOLINES;
D O I：
10.1080/10426509208034446
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
3-Cyanoquinoline-2(1H)-thione (1) was reacted with some halocompounds to give S-substituted thioquinoline derivatives 2, 6 and 7. Cyclization of 7 yielded thienoquinoline 8. Also, reaction of 1 with chloroacetone, chloroacetonitrile, ethyl chloroacetate and chloroacetamide furnished thienoquinolines 3, 4, 5 and 8, respectively. Moreover, compounds 4 and 8 underwent different sequence reactions to give some new pyrimido- and triazino-[4',5': 4,5]thieno[2,3-b]quinoline derivatives (9-21). Most of the prepared compounds were screened in vitro for their antibacterial activities.
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收藏
页码：219 / 227
页数：9
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