PARADOXICAL EFFECT OF CERIUM ON COLLAGEN-SYNTHESIS IN CARDIAC FIBROBLASTS

被引:32
|
作者
SHIVAKUMAR, K
NAIR, RR
VALIATHAN, MS
机构
[1] Division of Cardiomyopathy, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum
关键词
CERIUM; COLLAGEN SYNTHESIS; TRANSCRIPTION; ENDOMYOCARDIAL FIBROSIS;
D O I
10.1016/0022-2828(92)93391-V
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present study examined the effect of cerium on collagen synthesis in cultured cardiac fibroblasts and explants. At 100 nm, a concentration comparable with that found in the cardiac tissue of patients with endomyocardial fibrosis, the element was found to enhance the incorporation of tritiated proline into collagen and non-collagen proteins while at 10 μm, it had an inhibitory effect. Cerium was found to have no effect on rates of DNA synthesis in fibroblasts at 100 nm. However, at this concentration, the element markedly enhanced the incorporation of tritiated uridine into RNA, suggesting that cerium may act at the level of transcription to stimulate collagen and non-collagen protein syntheses. The stimulatory action of very low levels of cerium on collagen synthesis may contribute to the accumulation of collagen seen in endomyocardial fibrosis. © 1992.
引用
收藏
页码:775 / 780
页数:6
相关论文
共 50 条
  • [1] PARADOXICAL EFFECT OF PARAQUAT ON COLLAGEN-SYNTHESIS IN CULTURED FIBROBLASTS
    DARR, D
    MURAD, S
    COMBS, S
    PINNELL, S
    CLINICAL RESEARCH, 1992, 40 (02): : A481 - A481
  • [2] PARADOXICAL EFFECT OF PARAQUAT ON COLLAGEN-SYNTHESIS IN CULTURED FIBROBLASTS
    DARR, D
    MURAD, S
    COMBS, S
    PINNELL, S
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 98 (04) : 620 - 620
  • [3] COLLAGEN-SYNTHESIS BY SCLERODERMA FIBROBLASTS
    KRIEG, T
    PERLISH, JS
    MAUCH, C
    FLEISCHMAJER, R
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1985, 460 : 375 - 386
  • [4] EFFECT OF ASCORBATE ON COLLAGEN-SYNTHESIS BY LUNG EMBRYONIC FIBROBLASTS
    FARIS, B
    SNIDER, R
    LEVINE, A
    MOSCARITOLO, R
    SALCEDO, L
    FRANZBLAU, C
    IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION, 1978, 14 (12): : 1022 - 1027
  • [5] EFFECT OF MAST-CELLS ON COLLAGEN-SYNTHESIS BY FIBROBLASTS
    QIAN, YR
    DIEGELMANN, RF
    SCHWARTZ, LB
    IRANI, AA
    COHEN, IK
    FASEB JOURNAL, 1988, 2 (05): : A1589 - A1589
  • [6] THE EFFECT OF AMMONIUM ON PROLIFERATION AND COLLAGEN-SYNTHESIS IN KIDNEY FIBROBLASTS
    KNECHT, A
    SHULMAN, L
    HARMAN, M
    GAVENDO, S
    SERBAN, I
    RAPOPORT, J
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1995, 6 (03): : 898 - 898
  • [7] ALDOSTERONE AND COLLAGEN-SYNTHESIS IN CULTURED ADULT-RAT CARDIAC FIBROBLASTS
    BRILLA, CG
    ZHOU, G
    WEBER, KT
    FASEB JOURNAL, 1992, 6 (05): : A1914 - A1914
  • [8] COLLAGEN-SYNTHESIS BY SCLERODERMA FIBROBLASTS IN CULTURE
    JIMENEZ, SA
    BASHEY, RI
    ARTHRITIS AND RHEUMATISM, 1977, 20 (03): : 902 - 903
  • [9] THE EFFECT OF RETINOIC ACID ON COLLAGEN-SYNTHESIS BY HUMAN DERMAL FIBROBLASTS
    NELSON, DL
    BALIAN, G
    COLLAGEN AND RELATED RESEARCH, 1984, 4 (02): : 119 - 128
  • [10] EFFECT OF COLCHICINE ON COLLAGEN-SYNTHESIS BY LIVER FIBROBLASTS IN MURINE SCHISTOSOMIASIS
    MANSOUR, MM
    DUNN, MA
    SALAH, LA
    CLINICA CHIMICA ACTA, 1988, 177 (01) : 11 - 20