HYDROGEN-DEUTERIUM EXCHANGE IN LACTAMS

被引：20
作者：
CHEN, CYS
SWENSON, CA
机构：
[1] Department of Biochemistry, University of Iowa, Iowa City
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1969年 / 91卷 / 02期
关键词：
D O I：
10.1021/ja01030a002
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The kinetics of hydrogen-deuterium exchange have been measured for three cis lactams (butyrolactam, valerolactam, and caprolactam), the cis-trans lactam (caprylactam), and a trans amide (N-methylacetamide) in deuterium oxide solution. Exchange rates and activation energies (12-15 kcal/mole) are comparable for both the cis and trans configurations. Furthermore, activation energies are of a similar magnitude as those for other model peptides, polypeptides, and proteins. © 1969, American Chemical Society. All rights reserved.
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页码：234 / &
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