SYNTHESIS AND CHARACTERIZATION OF HYDROLYTICALLY LABILE POLY(PHOSPHOESTER URETHANES)

被引：0
|
作者：
SHI, FY [1 ]
WANG, LF [1 ]
TASHEV, E [1 ]
LEONG, KW [1 ]
机构：
[1] JOHNS HOPKINS UNIV, DEPT BIOMED ENGN, BALTIMORE, MD 21218 USA
来源：
ACS SYMPOSIUM SERIES | 1991年 / 469卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Biodegradable poly(phosphoester-urethanes) containing bisglycophosphite as the chain extender were synthesized. Methylene bis-4-phenyl isocyanate (MDI) and toluene diisocyanate (TDI) were initially used as diisocyanates. Since there was a concern that the degradation products could be toxic, the ethyl 2,6-diisocyanatohexanoate (LDI) was synthesized and replaced the MDI (or TDI). The hydrolytic stability and solubility of these polymers were tested. Preliminary release studies of 5-fluorouracil from MDI based poly(phosphoester-urethane) and methotrexate from LDI based poly(phosphoester-urethane) are also reported.
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页码：141 / 154
页数：14
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