A DOUBLE-BLIND-STUDY OF MISOPROSTOL (SC-29333) IN THE HEALING OF DUODENAL-ULCER

被引：1
|
作者：
AHMED, WU
QURESHI, HM
ALAM, E
ZUBERI, SJ
机构：
[1] PMRC Research Centre, Jinnah Postgraduate Medical Centre, Karachi
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 1991年 / 6卷 / 02期
关键词：
DUODENAL ULCER; MISOPROSTOL; PROSTAGLANDIN;
D O I：
10.1111/j.1440-1746.1991.tb01463.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In a double-blind randomized placebo controlled trial, 50 patients with endoscopically confirmed duodenal ulcer were treated with either misoprostol 200-mu-g or placebo in q.i.d. doses for 4-8 weeks. Of 25 patients in the placebo group, four defaulted and two were withdrawn due to worsening of symptoms. Of 25 misoprostol-treated cases, 17 cases (68%) and 21 cases (84%) healed at 4 and 8 weeks respectively, compared with three (14%) and five (24%) of the 21 placebo-treated cases (P < 0.001). Except for diarrhoea in 2 patients in each group and itching in one with misoprostol, no serious side effects were noted.
引用
收藏
页码：179 / 180
页数：2
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